Method for the preparation of sustained-release formulations of diltiazem

摘要

The present invention relates to a method for preparing a matrix granule by using a diltiazem hydrochloride diltiazem hydrochloride active material polymer and a fatty acid to prepare a primary granule by mixing an active material, a water-soluble polymer and an arabic rubber powder, The present invention relates to a method for producing a sustained-release formulation, which comprises mixing a water-soluble polymer and a fatty acid to prepare a second granule, mixing the first granule and the second granule, Gem's sustained-release formulations are new formulations in which the drug is evenly dispensed from the stomach to the stomach during long periods of time.