16 + 17 - acetal - substituted androstane - 17 - beta - carbonsaeureester, procedures to their manufacture and pharmaceutical praeparate containing them.

摘要

The invention relates to the preparation of a compound of the formula CHEM or a stereoisomeric compound thereof, in which formula the the l,2-position is saturated or is a double bond; X1 is selected from hydrogen, fluorine, chlorine and bromine X2 is selected from hydrogen, fluorine, chlorine and bromine R2 is selected from straight and branched hydrocarbon chains having l-l0 carbon atoms and R7 is hydrogen or an acyl group with l-l0 carbon atoms arranged in a straight or branched chain, characterized by reaction of a steroid compound of the formula CHEM with an aldehyde compound of the formula CHEM wherein X1, X2, R2, R7 and IMAGE have the meanings given above, in the presence of an acid catalyst. The products of the process are useful intermediates in the preparation of novel glucocorticosteroids which possess high anti-inflammatory potency at the place of application and low glucocorticord systemic potency.