nucleoside derivatives, particularly of 2 '- deoxycytidin, and their application in the synthesis of oligonucleotides.

摘要

Nucleoside derivatives and their use for the synthesis of oligonucleotides. …??These derivatives correspond to the formula: …IMAGE… in which R1 denotes the radical of formula:… -CO-CH2-C(R2R3)-R4… in which R2 and R3, which may be identical or different, denote a hydrogen atom or an alkyl radical, and R4 denotes an optionally substituted aryl radical, R5 denotes a hydrogen atom, the dimethoxytrityl radical or the radical R1, R6 denotes a hydrogen atom, the radical R1 or a radical suited for the synthesis of polynucleotides, and R7 denotes a hydrogen atom or the protected or unprotected hydroxyl radical. …??R1 may be the radical -CO-CH2-CH2-C6H5.