disposable device for use in chemical, immunochemischen and microbiological analyses.

摘要

In accordance with an embodiment of the present invention, a substantially rigid, multi-well, self-pipetting device for use in chemical, immunochemical and microorganism analysis is provided. The device includes a substantially rigid, substantially planar frame having, in operational orientation, a front face, a back face, a top edge and a bottom edge. A plurality of test wells are disposed within the device between the front face and the back face, usually in a linear array. A filling manifold is located within the device. The filling manifold is in fluid communication with each of the test wells through a filling passageway. A docking port is provided in the device which is adapted for receiving a reservoir holding a fluid specimen. The docking port is disposed on a peripheral surface of the device. The docking port is in fluid communication with the filling manifold through a filling port and a filling channel disposed within the device. With the device in its operational orientation, the test wells, filling channel, filling manifold and filling port are located at a level lower than the surface of the fluid in the reservoir. The device has a vent control system, also in fluid communication with the test wells, which is comprised of one or more vent manifolds, and/or valves to a vent manifold, and/or one or more vent holes or other passages to the ambient atmosphere. These vent holes, if present, are temporarily closed by a film or other means. With the device in its operational position, the vent manifold and/or vent holes of the vent control system are positioned higher than the surface of the fluid in the reservoir. The test wells are connected to the filling manifold and the vent control system according to the filling sequence. The reservoir is also connected to the vent control system through a vent port and a vent channel. The fluid specimen in the reservoir therefore flows down to the filling manifold by gravity and fills the test wells vented to the reservoir or to the ambient atmosphere.