A method for enantiomer separation on chiral modified separating a helicoidal guide surface, as well as electromigration failures in capillary columns

摘要

A process is disclosed for separating enantiomers by an electrokinetic process in capillary columns, using surface-immobilized chiral components. The chiral component used may be a polysiloxane to which alkylated cyclodextrine ( alpha , beta or gamma ) has been chemically bonded and which is immobilized on the surfaces located in the separation system, for example. This process is useful for qualitatively and quantitatively analyzing isomers, in particular enantiomers. In particular, it is not limited to non-decomposed volatile analytes, as in gas chromatography. A typical advantage of this process, besides its high resolution, is the long service life of the arrangement used. When it is used in addition to mobile phases, the separation components must be made available again after each analysis operation.