Transdermal aspirin dosage forms - for antithrombotic therapy or cancer prophylaxis

摘要

Transdermal dosage forms for antithrombotic therapy and/or cancer prophylaxis contain aspirin (acetylsalicyclic acid) and/or its salts. The dosage forms are patches, creams or ointments. Patches comprise an impermeable backing layer, an aspirin-contg. polymer matrix, a release-controlling membrane, and adhesive layer, and opt. a release liner. The aspirin content is 5-500 (esp. 30-200) mg. Permeation through the skin may be enhanced by applying an electric current or adding a penetration enhancer. USE/ADVANTAGE - Antithrombotic therapy is defined as embracing prevention of myocardial infarction and re-infarction, treatment of unstable angina, prophylaxis of thrombosis after implantation of vascular prostheses or artificial heart valves, prophylaxis of peripheral arterial thrombosis, and prophylaxis of thrombosis associated with cerebral ischaemia. Cancers to be prevented include those involving gastrointestinal (e.g. colonic) tumour formation. The aspirin is introduced directly into the blood stream in active form without being metabolised in the gastrointestinal tract. Compared with oral dosage forms, gastrointestinal side effects are reduced, dosages are reduced, risk of overdose is reduced and patient compliance is improved