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PEPTIDE FRAGMENTS FROM HUMAN CYTOCHROME P450 IID6, PEPTIDE ANTI-FRAGMENT ANTIBODIES AND THEIR APPLICATIONS IN THE DIAGNOSIS OF AUTOIMMUNE HEPATITIS.
PEPTIDE FRAGMENTS FROM HUMAN CYTOCHROME P450 IID6, PEPTIDE ANTI-FRAGMENT ANTIBODIES AND THEIR APPLICATIONS IN THE DIAGNOSIS OF AUTOIMMUNE HEPATITIS.
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机译:人类细胞色素P450 IID6的肽片段,肽抗片段抗体及其在自身免疫性肝炎诊断中的应用。
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摘要
Human P450 IID6 cytochrome-derived peptide fragments, anti peptide anti fragment antibodies and applications thereof in the diagnosis of autoimmune hepatitis and more especially in the differential diagnosis between autoimmune hepatitis and other chronc viral forms of hepatitis, such as hepatitis C or B. Said human P450 cytochrome peptide fragment contains at least one P450 IID6 cytochrome immunodominant epitope and consists of an amino acid sequence comprising from 3 to 70 amino acids. Said peptide binds specifically with anti-LKM auto-antibodies produced in autoimmune hepatitis.
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