Human P450 IID6 cytochrome-derived peptide fragments, anti- peptide fragment antibodies, applications thereof in the diagnosis of autoimmune hepatitis

摘要

Human P450 IID6 cytochrome-derived peptide fragments, anti peptide anti fragment antibodies and applications thereof in the diagnosis of autoimmune hepatitis and more especially in the differential diagnosis between autoimmune hepatitis and other chronic viral forms of hepatitis, such as hepatitis C or B. Said human P450 cytochrome peptide fragment contains at least one P450 IID6 cytochrome immunodominant epitope and consists of an amino acid sequence comprising from 3 to 70 amino acids. Said peptide binds specifically with anti-LKM auto- anitbodies produced in autoimmune hepatitis.