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Methods using estrogen receptor as a constitutive transcriptional activator and a repressor
Methods using estrogen receptor as a constitutive transcriptional activator and a repressor
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机译:使用雌激素受体作为组成型转录激活剂和阻遏物的方法
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摘要
The invention provides the discovery that estrogen receptor is a constitutive transcriptional activator and a repressor. These activities are lacking in the mutant estrogen receptor. The invention provides assays and methods for determining estrogen binding activity of ligands. The invention also provides therapeutic methods and the detection of pathologies associated with a mutated estrogen receptor.
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