Processes for preparing 2S-(2,3a,7a)octahydro-1H- indole-2-carboxylic acid and esters

摘要

The processes provide for the preparation of a [2S-(2, 3a, 7a)]-octahydro-lH-indole-2-carboxylic ester from an ester precursor by a stereospecific hydrogenation at a pressure below about 400 psi. In addition, the processes provide for the preparation of [2S-(2. alpha.m 3a, 7a)]-octahydro-lH-indole-2-carboxylic acid or a ester thereof by the hydrogenation of a (2S)-2-carboxyindoline acid precursor.