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kiraru intermediate field null for thiazole anti- diabetes glaze production
kiraru intermediate field null for thiazole anti- diabetes glaze production
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机译:kiraru噻唑类抗糖尿病釉的中间领域无效
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PCT No. PCT/US92/05434 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 1, 1992 PCT Pub. No. WO93/02061 PCT Pub. Date Feb. 4, 1993Two novel optically pure intermediates, (R)-4-(2-bromo-1-hydroxyethyl)-2- trifluoro(-)methylthiazole and (S)-4-oxiranyl-2-trifluoromethylthiazole, which have utility in the synthesis of a potent class of antidiabetic agents. The invention also embraces an enantioselective reduction process for their preparation.
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