3 - chloro - 2 - manufacturing method null of hydroxypropyl trimethylammoniumchloride

摘要

PURPOSE:To obtain a compound useful as a cation forming agent for starch, cellulose, etc., through efficient removal of unreacted epichlorohydrin and by- products by reacting an aqueous solution of trimethylamine hydrochloride with epichlorohydrin. CONSTITUTION:An aqueous solution of trimethylamine hydrochloride is reacted with epichlorohydrin in the molar ratio of epichlorohydrin to trimethylamine hydrochloride of 1.05-1.20, more than equimolar amount to give a crude aqueous solution of 3-chloro-2-hydroxypropyltrimehylammonium chloride. Then the crude aqueous solution is brought into contact with steam in counter current under reduced pressure by packed column method, formation of 1,3-dichlorohydrin as a by-product is suppressed and unreacted epichlorohydrin is removed to give the aimed purified substance. The steam distillation by packed column method shortens purification time and is advantageous in terms of amount of steam.