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SEQUENCE-SPECIFIC NONPHOTOACTIVATED CROSSLINKING AGENTS WHICH BIND TO THE MAJOR GROOVE OF DUPLEX DNA
SEQUENCE-SPECIFIC NONPHOTOACTIVATED CROSSLINKING AGENTS WHICH BIND TO THE MAJOR GROOVE OF DUPLEX DNA
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机译:与双链DNA的主要沟槽结合的序列特定的非光活化交联剂
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摘要
Agents which bind to the major groove of nucleic acid duplexes in a sequence-specific manner and are capable of forming covalent bonds with one or both strands of the duplex in the absence of light are useful therapeutic agents in the treatment of conditions mediated by duplex DNA. These agents are designed so that the reactivity of the crosslinking agent does not interfere with the sequence specificity of the agent which binds to the major groove. Thus, specific desired DNA duplexes can be targeted and their activity diminished or enhanced.
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