Medicine movement the cephalosporin derivative which is improved study, the manufacturing method, the medicine constituent, and the forming intermediate field null which include

摘要

New cephalosporin derivatives of formula: …IMAGE… in which:… - each of R1, R2 and R3 denotes a hydrogen atom or each of R1 and R2 denotes a hydrogen atom or a methyl group and R3 denotes a carboxyl group, or R1 and R2 taken together with the carbon atom to which they are linked form a cyclobutyl nucleus and R3 denotes a carboxyl group,… - the 2 groups A are different: one denotes a hydroxyl group and the other denotes a -NH-SO2-Alk-NH2 group in which Alk denotes a C2-C4 lower alkylene group,… and the pharmaceutically acceptable salts and esters of the said derivatives. …??The invention also relates to a process for their preparation, pharmaceutical compositions containing them and synthesis intermediates. …??The said derivatives exhibit improved pharmacokinetic properties.