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Process for producing conjugate of lactosaminated human albumin and adenine-9-β-D-arabinofuranoside 5'monophosphate
Process for producing conjugate of lactosaminated human albumin and adenine-9-β-D-arabinofuranoside 5'monophosphate
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机译:乳胺化人白蛋白与腺嘌呤-9-β-D-阿拉伯呋喃糖苷5'单磷酸酯结合物的制备方法
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摘要
For the preparation of conjugates of adenine-9-beta-D-arabinofuranoside 5'monophosphate (ara-AMP) with lactosaminated human albumin (L-HSA) aqueous solutions of the two components to be conjugated are brought into contact in the presence of 1-ethyl-3-(dimethylaminopropyl)-carbodiimide, by adjusting the pH in the range from slightly acidic to alkaline and by carrying out the conjugate separation. The resulting conjugate, wherein the molar ratio, as determined through spectrophotometric route, between ara-AMP and L-HSA does vary between 5 and 20, remains soluble after lyophilization even at room temperature and shows biological activity at least equivalent to that of the conjugate as prepared according to the known art.
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