METHOD FOR DISTINGUISHING HIGHLY INFECTIOUS HEPATITIS C VIRUS FROM LOW INFECTIOUS HEPATITIS C VIRUS

摘要

PURPOSE: To distinguish or separate highly infectious hepatitis C virus from low infectious hepatitis C virus in in-vitro. ;CONSTITUTION: A virus having ≤1.06g/ml density measured by centrifugal force in a liquid medium is regarded as a highly infectious hepatitis C virus and a virus having ≥1.13g/ml density is regarded as a low infectious hepatitis C virus. A virus to be examined is brought into contact with a human immunoglobulin antibody, a virus not to form an immune complex with an antihuman immunoglobulin antibody is regarded as a highly infectious hepatitis C virus and a virus to form an immune complex is regarded as a low infectious hepatitis C virus. A specimen of hepatitis C virus is brought into contact with an animal cell infected with retrovirus of mouse and then the animal cell is cultured. In the case where the specimen of the virus is replicated, the virus is regarded as a highly infectious hepatitis C virus and in the case where the specimen of the virus is not replicated, the virus is regarded as a low infectious hepatitis C virus.;COPYRIGHT: (C)1994,JPO&Japio