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Compound pharmaceutical formulation, processes for the preparation of factors a89271, factor a89271 and biologically pure culture of hapalosiphon hibernicus
Compound pharmaceutical formulation, processes for the preparation of factors a89271, factor a89271 and biologically pure culture of hapalosiphon hibernicus
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机译:复方药物制剂,a89271因子,a89271因子的制备方法和哈伯洛西芬的生物纯净培养物
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摘要
New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
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