PULSATING SYSTEMS FOR ADMINISTERING MINOCYCLIN ONCE A DAY

摘要

pharmaceutical systems containing 7 - dimethyl - 6 - - deoxy - 6 - demethyltetracyklin or its non-toxic addition sol with acids, containing mixtures of small percentage of slow releasing.blended polymer coated, spherical granules prepared for release of minocycline in a medium, having a ph below 3.9, and the rest in the range from about 4.0 to about 7.5 and the proportion of coated or uncovered quickly releasing granules prepared for release of minocycline in the medium, having a ph less than about 3.9 and are provided with capsule for oral administration.containing the above systems.these systems and products provide enhanced therapeutic levels of minocycline in the blood for at least 24 hours when the body only once a day, no matterif it is administered to fasting or with food. preparation methods and systems are provided pu0159u00edpravku016f.u0155