AMIDATED human calcitonin gene related peptide, to processes for producing such peptide and pharmaceutical composition containing such a peptide, AND gene encoding a fusion peptide comprising said peptide, vector comprising said gene, AND host organism, transformed with said vector

摘要

There is described human calcitonin gene related peptide. A peptide of the structure Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Argi -Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly- -Val-Val-Lys-Asn-Phe-Val-Pro-Thr-Asn- -Val-Gly-Ser-Lys-Ala-Phe-amide(I) is prepared either by chemical synthesis or by the use of recombinant DNA techniques. The peptide has potent biological activity on the cardiovascular function and it is described for use as a pharmaceutical in the treatment of hypertension. A pharmaceutical composition including the peptide is described either as an injectable composition or in a slow release system. Reagents for use in the immunoassay of the peptide are described as is a DNA hybridisation probe for use in an assay for a nucleotide coding for the peptide.