Process for the preparation of new therapeutically useful pyridatsiiniamiinijohdannaisten

摘要

Novel pyridazinamine derivatives of formula CHEM wherein R1 is hydrogen, C1-6alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C1-6alkyl)amino, cyano, C1-6alkyloxy, aryloxy, arylC1-6alkyloxy, C1-6alkylthio, arylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, arylsulfinyl, aryllsulfonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl or aryl; R2 and R3 each independently are hydrogen or C1-6alkyl, or R2 and R3 combined may form a bivalent radical of formula -CH=CH-CH=CH- G is a bivalent radical of formula CHEM X is O, S, NR8 or a direct bond; said R8 being hydrogen or C-6alkyl; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-virals; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.