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PROCESS FOR PRODUCTION OF STABILIZED MEDICAL PREPARATIVES CONTAINING FIBROBLAST GROWING FACTOR
PROCESS FOR PRODUCTION OF STABILIZED MEDICAL PREPARATIVES CONTAINING FIBROBLAST GROWING FACTOR
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机译:含有成纤维细胞生长因子的稳定药物制剂的生产过程
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摘要
Methods for stabilizing fibroblast growth factor (FGF) in heat, acid and/or proteolytic environments are provided. Such methods comprise combining or otherwise complexing FGF with a salt of sucrose octasulfate (SOS) and in particular with the aluminum (sucralfate) or potassium salts thereof. The present invention also provides FGF-stable compositions comprising SOS and FGF. Such compositions can be used in the treatment of FGF-responsive diseases including the treatment of wounds and ulcerative conditions of the gastrointestinal tract. The present invention also provides various diagnostic protocols employing SOS as well as diagnostic kits with SOS as a component thereof. Finally, the present invention provides methods of purifying FGF with SOS.
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