METHOD FOR PRODUCING AND PURIFYING PROTEINES HAVING EFFECT OF TUMOROUS NECROSIS FACTOR AND ANOTHER ONE FOR PREPARING PHARMACEUTICAL PREPARATIVES OF SYNERGETIC EFFECT CONTAINING SAID PROTEINES AND GAMMA-INTERFERON

摘要

Methods and compositions are provided for the purification of a protein identified as tumor necrosis factor from nonrecombinant and recombinant sources, the preparation of nucleic acid encoding this tumor necrosis factor and for its expression in recombinant hosts. This tumor necrosis factor is used in the therapeutic treatment of malignant tumors, either alone or in synergistic combination with an interferon.