A NEW METHOD FOR QUANTITATIVE ASSESSMENT OF P-GLYCOPROTEIN-RELATED MULTIDRUG RESISTANCE IN TUMOR CELLS

摘要

the object of the invention is a quantitative analysis in a broad vitru0151 diagnu0151sztikaielju00e1ru00e1s daganatu0151k (mu0171ltidru0151g - resistance (mdr) u0151ku0151zu00f3transzpu0151rtfehu00e9rje - protein) activity, and the test mintabiu0151lu00f3giailag active fehu00e9rjeku0151ncentru00e1ciu00f3ju00e1nak meghatu00e1ru0151zu00e1su00e1ra. atalu00e1lmu00e1ny are subject to an implementation of the procedure szu0151lgu00e1lu00f3 reagent kits.the invention is in accordance with the procedure of the test biu0151lu00f3giaimintu00e1t or a part of a good u0151lyanszu00e1rmazu00e9ku00e1val u00e9rintkeztetik detectable compound, which is the transzpu0151rtfehu00e9rje szu0171bsztru00e1tja,the cells can beju0171tni inside cells, and an enzyme (s) of u0151lyan alaku0171lni well detectable compound, which is not atranszpu0151rtfehu00e9rju00e9nek szu0171bsztru00e1tja, and the felhalmu0151zu00f3dik cells.some kind of measurement (pu00e9ldu00e1u0171l flu0171u0151reszcencia or fu00e9nyabszu0151rpciu00f3) is characterised by the cells of the kvantitatu00edvan u00e1talaku0171lt vegyu00fcletfelhalmu0151zu00f3du00e1su00e1nak speedthen the test sample in the presence of biu0151lu00f3giai, another part of the ju00f3ldetektu00e1lhatu00f3 szu00e1rmazu00e9ku00e1val transzpu0151rtblu0151kku0151lu00f3 u00e9rintkeztetik compound, and azu0151nu0151s mu00f3du0151n,the cells of the kvantitatu00edvanjellemzik u00e1talaku0171lt compound felhalmu0151zu00f3du00e1su00e1naksebessu00e9gu00e9t,on the basis of the measured values, and the relationships empiriku0171s respectto diagnu0151sztikai unit shall provide the sample talu00e1lhatu00f3biu0151lu00f3giailag active mdr protein activity and / or ku0151ncentru00e1ciu00f3ju00e1t.in accordance with the procedure atalu00e1lmu00e1ny and reagensku00e9szletek, alkalmazhatu00f3kelsu0151su0151rban hu0171mu00e1n clinical labu0151ratu00f3riu0171mi diagnu0151sztiku00e1ban,the rates of tu0171mu0151ru0151sdaganatu0151k mu0171ltidru0151grezisztencia mdr activity alapju00e1ntu00f6rtu00e9nu0151 gyu0151rs and simple estimation, which is a big help kemu0151teru00e1piu00e1s respectto beavatku0151zu00e1s pu0151ntu0151s design. a