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Kompleksa 'Faktors-YIII + fon Villebranda faktors' koncentrata iegusanas metode
Kompleksa 'Faktors-YIII + fon Villebranda faktors' koncentrata iegusanas metode
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机译:复杂的“ Faktors-YIII + fon Villebranda faktors” Koncentrata iegusanas metode
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摘要
The invention relates to a process for the preparation of a concentrate of complex factor viii inhibitors - von willebrand factor at a high specific activity on the basis of total plasma cryoprecipitate (,). br / the method comprises a prepurification involving a double treatment with the barium chloride and the aluminum hydroxide (br / the method then comprises a purification by chromatography on anion exchange resin, deae - fractogel. & br / the method comprises a viral inactivation step by a treatment with the solvent detergent -. & br / the method also makes it possible to recover the fibrinogen, albumin, immunoglobulins, antithrombin iii and fibronectin, from the same plasma. & br / the different concentrates obtained by the process of the invention are intended especially for therapeutic use.
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