New Derivatives of mecaptoacetilamido piridazo pyrazolo pyridazine hydrochloride (1,2), (1, 2) pyridazine hydrochloride, piridazo (2 - 1) (1, 2) and diazepina pyrazolo (2 - 1) (1, 2) diazepina,Useful as inhibitors of Ace and encefaliasa

摘要

Enkephalinase, or more specifically, the ectoenzima Endopeptidase 24.11 is a Mammal, which is involved in the Metabolic degradation of certain Regulatory peptides in circulation.This Enzyme, which is a metalopeptidasa Zn + 2,Exerts its effect on the Unfolded peptides in the extracellular amino Group of hydrophobic residues and inactive in the regulatory peptides as Messengers.Enkephalinase is involved in the Metabolic degradation of a variety of Regulatory peptides circulating, including endorphins, such as beta - endorphins and enkephalins,Atrial natriuretic peptide (ANP) and other regulatory peptides circulating.