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Anvendelse av terfenadinderivater som antihistaminmidler i en hepatisk svekket pasient
Anvendelse av terfenadinderivater som antihistaminmidler i en hepatisk svekket pasient
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机译:特非那定衍生物作为抗组胺药在肝功能不全患者中的应用
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摘要
The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of formula (I) wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; R3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A and B is hydrogen or hydroxy with the proviso that at least one of A or B is hydrogen; or a pharmaceutically acceptable salt and individual isomers thereof.
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机译:本发明涉及一种在有需要的肝功能不全患者中提供抗组胺作用的方法,该方法包括向所述患者施用有效的抗组胺量的式(Ⅰ)化合物,其中R 1为氢或羟基。 R 2是氢;或者R1和R2一起在带有R1和R2的碳原子之间形成第二键; n为1至5的整数; R3是-COOH或-COO烷基,其中烷基部分具有1-6个碳原子并且是直链或支链的; A和B各自为氢或羟基,条件是A或B中至少一个为氢。或其药学上可接受的盐及其单个异构体。
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