PREPARATION OF 13-BETA-22,23-DIHYDRO AVERMECTIN AGLYCONES USING STREPTOMYCES CULTURES; THE STRAINS MA-6762 AND MA-6763

摘要

The known compound, 13 beta -13-deoxy-22,23-dihydro-avermectin -Bla/Blb Aglycone is prepared microbiologically from cultures of the novel microorganisms (MA-6762, ATCC 55069, MA-6763 ATCC 55070) or the known microorganism Streptomyces lavendulae MA-6555 (ATCC 14159). The compound is prepared by the biotransformation of 13-deoxy-22,23-dihydro avermectin Bla/Blb aglycone which oxidizes the 13-position and epimerizes the 13-position hydroxy group.