PREPARATION OF AN ERYTHROAMINOALCOHOL THROUGH REACTION OF A CYANOHYDRIN DERIVATIVE AND A GRIGNARD REAGENT FOLLOWED BY TRANSIMINATION AND DEPROTECTION

摘要

The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resulting imine and removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the cyanohydrin derivatives.