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esters of acyl - l - carnitine acid gamma - idrossibutirrico and pharmaceutical compositions containing them for the inhibition of neuronal degeneration and for the treatment of coma.
esters of acyl - l - carnitine acid gamma - idrossibutirrico and pharmaceutical compositions containing them for the inhibition of neuronal degeneration and for the treatment of coma.
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机译:酰基-1-肉碱酸γ-异丁烯酸酯和含有它们的药物组合物的酯,用于抑制神经元变性和治疗昏迷。
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摘要
The esters of acyl L-carnitines with gamma-hydroxybutyric acid in the form of pharmacologically acceptable salts of formula (I) CHEM wherein X- is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate or in the form of inner salts of formula (I min ) CHEM wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms, such as e.g. acetyl, propionyl, n-butyryl, isobutyryl and isovaleryl, are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.
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