the l - carnitine esters and acyl - l - carnitine acid beta - idrossibutirrico and pharmaceutical compositions containing them for the inhibition of neuronal degeneration.proteolysis and in the treatment of hepatic coma.

摘要

The esters of (R)(-)-carnitine and acyl (R)(-)-carnitines with beta-hydroxybutiric acid in the form of pharmacologically acceptable salts of formula (I) CHEM wherein X- is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate or in the form of inner salts of formula (I min ) CHEM wherein R is hydrogen or a straight or branched acyl group having from 2 to 5 carbon atoms, such as e.g. acetyl, propionyl, n-butyryl, isobutyryl and isovaleryl, are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease), liver proteolysis and in the treatment of coma.