ANTITUMOR 6-SULFENAMIDE, 6-SULFINAMIDE AND 6-SULFONAMIDE PURINE, PURIN NUCLEOSIDE, PURIN NUCLEOTIDE AND RELATED COMPOUNDS.

摘要

6-Sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and 3 and 7 deaza and 8 aza derivatives thereof of structure: IMAGE wherein Z is H or -NH2; X is -S-NH2, IMAGE T is C-H, G is N and Q is N; or T is C-H, G is N and Q is C-H; or T is N, G is N and Q is C-H; or T is C-H, G is C-H and Q is N; Y is H or an alpha -pentofuranose or beta -pentofuranose of the formula: IMAGE wherein R1 and R2 independently are H, OH, -O-acyl or IMAGE or together R1 and R2 are IMAGE and R3 and R4 are H or one of R3 or R4 is OH and the other is H; provided that when Y is H, Z is -NH2; and acceptable salt thereof are prepared and are useful as antitumor agents or they are intermediates for compounds which are antitumor agents. The compounds are used to treat an affected warm blooded host by serving as the active ingredients of suitable pharmaceutical compositions.