ANGIOGENIC FACTOR OF HUMAN PLACENTA ABLE TO STIMULATE CAPILLARY SYNTHESIS OF ENDOTHELIAL CELL PROTEASE, DNA SYNTHESIS AND MIGRATION.

摘要

AN ANGIOGENIC FACTOR HAS BEEN DISCOVERED, WHICH IS A PURIFICATION OF A SIMPLE POLYPEPTIDIC PROTEIN CHAIN WITH AT LEAST ONE ACTIVE CENTER WITH NITOGENIC ACTIVITY, CHEMOTOTIC ACTIVITY, CAPACITY TO STIMULATE PROTEIN SYNTHESIS AND COMBINATIONS OF BOTH. THIS ANGIOGENIC FACTOR PRESENTS THE SAME IMMUNOLOGICAL EQUIVALENT AS ISOLATED ANGIOGENIC FACTORS FROM HUMAN PLACENTA TISSUES. THE AMINO ACID SEQUENCE OF THIS ANGIOGENIC FACTOR HAS ALSO BEEN DISCOVERED. IN ADDITION, A METHOD FOR ISOLATING THE PURIFIED ANGIOGENIC FACTOR OF HUMAN PLACENTA TISSUES IS ESTABLISHED FORWARD. PHARMACEUTICAL PREPARATIONS HAVE BEEN DESCRIBED INCORPORATING THIS ANGIOGENIC FACTOR.