Hla-dr3 blocking peptides and their use in the treatment of hla-dr3 associated autoimmune diseases.

摘要

A peptide comprising the amino acid sequence: An-1 An An+1 An+2 An+3 An+4 An+5 wherein An-1 is any amino acid; An is I, L or V; An+1 is A, H or Q; An+2 is Y, S, R or P; An+3 is D, E or Q; An+4 is E or D; An+5 is any amino acid; with the proviso that said sequence differs by one amino acid substitution from the sequence T I A Y D E E. Use of the peptide which has an HLA DR3 blocking activity in a treatment of HLA DR3 related autoimmune diseases.