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CLONING AND CHARACTERIZATION OF THE CELL DEATH GENES CED-3 AND CED-4
CLONING AND CHARACTERIZATION OF THE CELL DEATH GENES CED-3 AND CED-4
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机译:细胞死亡基因CED-3和CED-4的克隆和鉴定
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摘要
Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized.
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