NOVEL TIGHT-BINDING INHIBITORS OF LEUKOTRIENE A4 HYDROLASE

摘要

Inhibitors of leukotriene A4 hydrolase are disclosed, as are processes for making and using the same. A contemplated inhibitor has a structure corresponding to formula (I), wherein the depicted -NH2 group is in the (S) configuration; -W is -CH2SH, -CH2NH2 or C(=Z)-Y, wherein =Z is =O, or -H and -OH; and -Y is selected from the group consisting of (a) phenyl, (b) trifluoromethylphenyl, (c) carboxyphenyl, (d) benzyl, (e) C1-C6 alkylenecarboxyl, (f) C1-C6 alkyl, (g) C2-C6 alkenyl, (h) C1-C6 alkylenephenyl and (i) -C(=O)-X-R1 wherein X is O or NH and, R1 is selected from the group consisting of C？1?-C6 alkyl, C1-C6 alkylenecarboxyl, and benzyl, with the proviso that -Y is other than (i) when =Z is -H and -OH; and R?2？ is hydrogen, benzyloxy or 2-naphthylmethyloxy, and a pharmaceutically acceptable acid addition salt thereof.