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ASCOFURANONE, AND HYPOLIPIDEMIC AGENT, HYPOGLYCEMIC AGENT AND GLYCATION INHIBITOR EACH CONTAINING ASCOFURANONE DERIVATIVE AS ACTIVE INGREDIENT
ASCOFURANONE, AND HYPOLIPIDEMIC AGENT, HYPOGLYCEMIC AGENT AND GLYCATION INHIBITOR EACH CONTAINING ASCOFURANONE DERIVATIVE AS ACTIVE INGREDIENT
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机译:含有呋喃酮衍生物作为活性成分的抗坏血酸酮,降糖剂,降血糖剂和糖化抑制剂
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摘要
An ascofuranone derivative represented by general formula (II) (wherein R1 represents lower alkylcarbonyl, pyridylcarbonyl, benzoyl substituted by one lower alkyl or alkoxy group, toluenesulfonyl, carbamoyl substituted by one or two lower alkyl groups, or lower alkyl substituted by lower alkoxycarbonyl); a hypolipidemic agent containing the same as the active ingredient; and a hypoglycemic agent or a glycation inhibitor each containing an ascofuranone derivative represented by general formula (I) (wherein R represents hydrogen, lower alkylcarbonyl, pyridylcarbonyl, benzoyl substituted by one lower alkyl or alkoxy group, toluenesulfonyl, carbamoyl substituted by one or two lower alkyl groups, or lower alkyl substituted by lower alkoxycarbonyl) as the active ingredient. The compounds represented by the above general formulae (I) and (II) are excellent in hypoglycemic, hypolipidemic and glycation-inhibiting effects, thus being remarkably useful for preventing and treating diabetes, arteriosclerosis and so forth.
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