METHOD OF LOWERING INTRAOCULAR PRESSURE BY ADMINISTERING A PHARMACEUTICAL COMPOSITION CONTAINING 7-(5-SUBSTITUTED CYCLOPENTYL) AND 7-(5-SUBSTITUTED-CYCLOPENTENYL)-5-HEPTENOIC ACIDS AND DERIVATIVES

摘要

Intraocular pressure is lowered in the eye of a mammal by administration of a pharmaceutical composition containing as active ingredient a compound of formula (1), where the dotted line represents a bond or the absence of a bond, wavy lines connected to the olefinic bond represent cis or trans configuration about the olefinic bond; R1 represents H, or CO-R3 where R3 is lower alkyl of 1 to 6 carbons, carbocyclic aryl or heterocyclic aryl; or carbocyclic aryl or heteroaryl substituted lower alkyl group; R2 represents H or lower alkyl of 1 to 6 carbons, and n is an integer between 0 and 8.