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Peptides having tachykinin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same
Peptides having tachykinin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same
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机译:具有速激肽拮抗剂活性的肽,其制备方法和包含该肽的药物组合物
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摘要
A compound of forumula: CHEM wherein R1 is aryl, or a group of the formula : CHEM wherein X is CH or N, and Z is O or N-R5, in which R5 is hydrogen or lower alkyl, R2 is hydroxy or lower alkoxy, R3 is hydrogen or lower alkyl which may have suitable substituent(s), R4 is ar(lower)alkyl which may have suitable substituent(s), A is carbonyl or sulfonyl, and Y is bond or lower alkenylene, and pharmaceutically acceptable salt thereof, processes of their preparation and pharmaceutical compositions comprising them as an active ingredient in admixture with pharmaceutically acceptable carriers.
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