Peptides having tachykinin antagonistic activity, a process for their preparation and pharmaceutical compositions comprising them.

摘要

A compound having the formula: wherein R HIGH 1 is aryl, or a group of the formula: wherein: X is CH ON, YZ ES OO NR ELEVATED 5 wherein R ELEVATED 5 is hydrogen or lower alkyl R (SQUARED ) is hydroxy or lower alkoxy, R ELEVATED 3 is hydrogen or lower alkyl MAY SUBSTITUTE (S) APTOS, R ELEVATED 4 is Ar (lower) alkyl which may have SUBSTITUTE (S) APTOS, A is carbonyl or sulphonyl, EY ES LINK or lower alkenylene, a salt thereof and pharmaceutically acceptable, process for their preparation and pharmaceutical compounds containing them as active ingredient mixed with pharmaceutically acceptable carriers.