Method of reducing or preventing toxicity associated with antiretroviral therapy by stimulation of the intracellular gluthatione level

摘要

The present invention provides a method for reducing, or preventing, the toxicity associated with antiretroviral therapy. To this end, when a glutathione intracellular stimulator is administered to a patient receiving antiretroviral therapy, the toxicity associated with such an agent is reduced. In a preferred embodiment, the antiretroviral therapy comprises AZT and DDI. Preferably, the composition for stimulating the intracellular glutathione levels comprises L-2-oxothiazolidine-4-carboxylate. The present invention also provides a method for treating a patient who is HIV positive, or who has AIDS, comprising the step of administering to the patient an antiretroviral therapy and administering to the patient an intracellular glutathione level in a sufficient amount to reduce the toxicity of the antiretroviral therapy.