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Method of reducing or preventing toxicity associated with antiretroviral therapy
Method of reducing or preventing toxicity associated with antiretroviral therapy
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机译:减少或预防与抗逆转录病毒疗法相关的毒性的方法
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摘要
The present invention provides a method for reducing, or preventing, the toxicity associated with antiretroviral therapy. To this end, when a glutathione intracellular stimulator is administered to a patient receiving antiretroviral therapy, the toxicity associated with such an agent is reduced. In a preferred embodiment, the antiretroviral therapy comprises AZT and DDI. Preferably, the composition for stimulating the intracellular glutathione levels comprises L-2-oxothiazolidine-4-carboxylate. The present invention also provides a method for treating a patient who is HIV positive, or who has AIDS, comprising the step of administering to the patient an antiretroviral therapy and administering to the patient an intracellular glutathione level in a sufficient amount to reduce the toxicity of the antiretroviral therapy.
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