INDUCTION OF IMMUNE RESPONSE AGAINST TETANUS TOXIN THROUGH ADMINISTRATION OF MYCOBACTERIA EXPRESSING TETANUS TOXIN OR FRAGMENTS

摘要

A method of inducing in an animal an immune response to tetanus toxin by administering mycobacteria transformed by a sequence of at least DNA encoding a protein or polypeptide that produces antibodies against tetanus toxin or a fragment or a is derived from this toxin. According to one of the provided embodiments, the immune response to tetanus toxin is induced by administering to the animal a vaccine including BCG which has been transformed by a DNA sequence of expression vector encoding the C of tetanus toxin.