3-Oxadiazolyl-1,6-naphthyridine derivatives with affinity for benzodiazepine receptors

摘要

A 3-Oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphthyridine derivative of the formula (I) :wherein Het is an oxadiazole ring, R₁ is hydrogen atom, an acyl group, a lower alkyl group or a group of the formula: -CH₂R₁' (in which R₁' is a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, benzyl group, aryl group or a heteroaromatic group), R₂ is a lower alkyl group, a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, aryl group, a heteroaromatic group, a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a phenoxy group or a lower alkylthio group, or a pharmaceutically acceptable acid addition salt thereof, is useful as benzodiazepine receptor agonist.