Imidazo(1,2-c)quinazoline derivates as antihyper tensives and anti dysurics

摘要

Compounds of formula wherein:X is O or S;R₁ is hydrogen, alkyl, phenyl or phenyl(alkyl);R₂ is hydrogen, alkyl, phenyl or phenyl(alkyl); or R₁ andR₂ together represent alkylene or wherein R₅ represents (a) 2-(2-hydroxyethoxy)ethyl; (b) pyrimidinyl; (c) a 2-, 3- or 4-pyridinyl optionally substituted by alkyl; and (d) benzoyl, benzyl,phenyl and diphenylmethyl optionally substitutedby halogen, methoxy, trifluoromethyl, alkyl, nitro, acetyl, and cyano; and(i) R₆ and R₇ together represent alkylene or (ii) or (iii) when R₆ represents hydrogen atom or hydroxy, R₇ represents (a) pyrimidinyl; (b) a 2-, 3- or 4-pyridinyl optionally substituted by alkyl; and (c) benzoyl, benzyl, phenyl and diphenylmethyl optionally substituted halogen, methoxy, trifluoromethyl, alkyl, nitro, acetyl, and cyano;R₃ is halogen, hydrogen, alkyl, trifluoromethyl, or alkoxy;R₄ is halogen, hydrogen, alkyl, trifluoromethyl, or alkoxy; andR₈ is hydrogen, alkyl or phenyl(alkyl).;These compounds are found useful as an active ingredient for the treatment of hypertension and dysuria.