Benzylidene- and cinnamylidine-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells

摘要

57 There are provided pharmaceutical compositions containing as an active ingredient a compound of the general formula (I):wherein R₁ and R₂ are each independently CN, CONH₂ or COOH or one of R₁ ad R₂ may be -CSNH₂ or, when R₁ is CN, R₂ can also be the groupR₃ is H, CH₃ or OH,R₄, Rs, R₆, R₇ are each independently H, OH, C_1-5 alkyl, C_1-5 alkoxy, NH₂, CHO, halogen, N0₂ or COOH, or R₄ and R₅ together may represent a group -O-CH₂-O-;provided that: (a) when R₄ ad R₇ are each OH, R₃, R₅ and R₆ are each H and one of R₁ and R₂ is CN, then the other of R₁ and R₂ cannot be CONH₂; and (b) when R₃ and R₇ are each H, R₅ is OH and R₄ and R₆ are both H or both C_{1 -5} alkyl, then R₁ is CN and R₂ is CN or the groupor a pharmaceutically acceptable salt thereof.;There are also provided some novel compounds of formula (I) above.;The compositions and compounds according to the invention are efficient protein-tyrosine kinase inhibitors and are suitable for the inhibition of proliferative processes in mammalian cells.