A cosurfactant system comprising a complement system inhibitor and an immunosuppressive compound and a water soluble body of water

摘要

The present invention relates to a combination of an organic and a biological component which inhibits a complement system or has an immunosuppressive activity, and relates to the therapeutic use of these compounds and their therapeutic use. The organic component water of the present invention is an ingredient exhibiting immunosuppression or exhibiting anti-inflammatory activity. Such organic constituents include K-76, K-76COOH and their analogues, synthetic derivatives, antimetabolites, antimitotic drugs, cyclosporins, steroids, and non-steroidal anti-inflammatory agents. In particular, the organic constituents of the present invention include substituted dihydrobenzofuran, substituted or unsubstituted cyprofibrogen-2 (3H)-cycloalkynes and their open chain intermediates having inhibitory activity. The biological component of the present invention is a soluble portion of a complementary system receptor having SCR motifs capable of inhibiting complementary system activity, or fragments thereof. The biological component water has at least one function associated with a complement system acceptor or associated with a protein containing SCR. The present invention relates to the use of mixtures of these constituents in the treatment of immune and / or inflammatory diseases.