T cell epi-trops of major allergens from house dust mites (HOUSE DUST MITE) to major allergens from house dust mites (house dust mite)

摘要

The present invention provides isolated peptides of the main protein allergen of D. dermatophagoides. Peptides within the scope of the present invention include at least one T cell epitope of a protein allergen selected from allergens Der p I, Der p II, Der f I or Der f II and also preferably at least two epitopes.;The invention also has similar or improved therapeutic properties such as the corresponding naturally occurring allergens or parts thereof. But relates to modified peptides with reduced negative effects. The present invention further provides methods of treating or diagnosing susceptibility to house dust mites in individuals and therapeutic compositions comprising one or more peptides of the invention.