DERIVATIVE OF 4-OXO-3H- PHTHALAZINE -1-ACETIC ACID, A METHOD OF SYNTHESIS OF 4-OXO-3H- PHTHALAZINE-1- ACETIC ACID ALKYL ESTER DERIVATIVES

摘要

FIELD: organic chemistry. SUBSTANCE: product: derivatives of 4-oxo-3H-phthalazine-1-acetic acid of the general formula I, , where R₁ - C₁-C₆-alkyl - are intermediate compounds. Products of the general formula II (image), where R₁ - C₁-C₆-alkyl; R₂ and R₃ are similar or different and mean hydrogen, fluorine, chlorotrifluoromethyl. Reagent 1 - according to formula III, , where W - CN-group or C(S)NH₂. Reagent 2 - according to formula IV, (R₂, R₃)C₆H₂-NO₂-Cl (IV). Reaction conditions: hydrogen sulfide, tertiary amine. EFFECT: improved method of synthesis. 3 cl