Compsn. for prophylaxis of the haemolytic disease of the new-born

摘要

Compsn. comprises a mixt. of at least 2 human monoclonal antibodies (MAbs), one of sub-class IgG1 and one of sub-class IgG2, which each recognise Rhesus D, but not C, c, E or e antigens and whose combination permits the detection of the majority of partial D antigens. The MAb of sub-class IgG1 is produced by the heterohybridoma (HH) cell line DSM ACC 2039, and the MAb of sub-class IgG3 is produced by the HH cell line DSM ACC 2040. Also claimed are the human/mouse HH cell lines as filed with the 'Deutsche Sammlung von Mikroorganism and Zellkulfuren, DSM ACC 2039 and 2040. The mixt. of the two Abs pref. comprises 30-70% of IgG3 and the cell lines are not EBV transformed.