New biodegradable homo- and co-polymer(s) for pharmaceutical use - produced by polycondensation of prod. from heterolytic cleavage of aliphatic polyester with functionalised (cyclo)aliphatic cpd.

摘要

New biodegradable homo- and co-polymers (I) are produced by: (a) heterolytically cleaving an aliphatic polyester with an aliphatic or cycloaliphatic cpd. contg. at least 2 functional substits.; and (b) polycondensing the prod. while eliminating low mol. wt. reaction prods.. USE/ADVANTAGE - (I) are useful as matrix materials for depot and controlled release drug formulations (e.g. of peptides, steroids, cytostatics and antibiotics) in human and veterinary medicine and for resorbable surgical sutures, etc.. The method does not have the limitations of prior art processes (e.g. described in DE3430852 and DE4308852). In partic., a wider range of linear polymers having partic. solubility properties can be produced.